Microparticle compositions for treatment of infection or disease, methods of making the same, and methods of treating subjects with microparticle compositions

ABSTRACT

Provided are microparticle compositions, methods of making the compositions, and methods of treating a subject with the present microparticle compositions by administering an effective amount of the microparticle composition for treating an infection or disease, to a subject in need thereof. The present microparticle compositions may include microparticles of essential oils, herbs, and/or supplements. By way of non-limiting example, the microparticle compositions may be particularly effective in the treatment of a Lyme tick borne illness related infection or disease, or a coronavirus, such as COVID-19. Also included are kits that include one or more of the present microparticle compositions and/or one or more components of the present compositions, and optionally one or more components, such as a device to aid in the delivery of the composition and/or instructions for administration.

FIELD

The present disclosure relates generally to microparticle compositionsfor treatment of infection or disease, methods of making suchcompositions, and methods of treating a subject with the presentmicroparticle therapy compositions. The present disclosure also includeskits that include one or more of the present microparticle compositionsand/or one or more components of the present compositions, andoptionally one or more components, such as a device to aid in thedelivery of the composition and/or instructions for administration.

BACKGROUND

According to current estimates, the prevalence of Lyme diseaseinfections is estimated to range from a low of 329,000 cases by theCenters for Disease Control (CDC) to a high of over 2,000,000 by 2020.

Current standards of treatment for tick-borne infections employantibiotic medications, which may drive the creation of debilitating ordeadly infections. Unfortunately, these medications have been shown toproduce drug-resistant mutant germs that can survive despite beingtreated with multiple rounds of antimicrobial drugs. Drug resistantforms of tick-borne infections including: Borrelia, Babesia, Bartonella,Ehrlichia, and Anaplasmosis have been identified. Medical providers aredeeply concerned that as more and more patients receive antibiotictreatment these infections will eventually become increasingly resistantto their limited number of antimicrobial drugs.

Drug resistance is a global concern, with drug resistant infections arerising worldwide. According to the World Health Organization (WHO),approximately 700,000 deaths worldwide every year are due todrug-resistant infections. These and other factors have led the WHO topredict a dramatic increase in the severity of drug resistantinfections. Deaths from drug-resistant infections are estimated to riseto 10 million worldwide by 2050.

The wide-spread excess use of antibiotics in livestock for the purposeof increasing animal weight, not for treating infections, is believed tobe a major driver of mutations of new multidrug resistant superbugs.Drug resistant tick-borne infections may arise in these same livestock.

Tick infections are also ripe for developing multidrug resistantsuperbugs in these same livestock that get infected from tick bites andare over treated with antibiotics. These superbugs may be spread throughthe environment by blood sucking ticks that feed on these superbuginfected livestock and crawl off to infect humans, pets, and otheranimals. The superbug microbes have been found in the manure and waterrunoff of these large-scale factory farms. These highly resistant germshave also been found in underground well water near these farms whereconditions are highly favorable for their growth. These superbugs mayalso be spread when contaminated water is used for drinking or wateringcrops. Given that the FDA has left it up to pharmaceutical companies toregulate antibiotic use for increasing livestock weight, it is likelythat we will see increased drug resistance in tick borne infections.

Also of concern, multiple tick-borne infections including Powassanfever, Heartland virus, Colorado tick fever, Tick-borne encephalitis,Bourbon virus, and southern tick-associated rash illness (STARI) arelacking any effective medications according to the CDC.

SUMMARY

Non-antibiotic therapy compositions would be advantageous for treatmentof tick-borne illnesses, as well as for other illnesses.

The present disclosure relates generally to microparticle compositionsor microparticle therapy compositions, kits including such compositionsand/or components thereof, methods of making such compositions, andmethods of treating a subject with the present microparticlecompositions by administering an effective amount of a composition tothe subject, to treat one or more infections or disease in the subject.

By way of non-limiting example, the present microparticle therapycompositions may include a liposome, nanoparticle, nanostructured lipidcarriers (NLCs), or nano-emulsion composition that includes one or moreof the following: GRAS (generally recognized as safe) essential oils,herbs, and supplements, including those presently available, as well asthose that maybe identified and become available in the future.According to non-limiting examples, the present compositions may beformulated in amount and type of ingredients, based on the presentinventor's discoveries, to achieve the desired advantageous resultsdiscovered by the present inventor.

Non-limiting examples of infections that may be treated using thepresent compositions and methods may include bacterial, viral and/orfungal infections. By way of non-limiting example, the invention mayinclude one or more Lyme tick borne infections or diseases, or acoronavirus infection, such as COVID-19.

Methods of treatment may include treating a subject/patient having aninfection with one or more of the present microparticle compositions, byadministering an effective amount of the composition(s) to asubject/patient in need of such treatment.

Also included herein are kits that include one or more of the presentmicroparticle therapy compositions or one or more components of saidcompositions and optionally one or more components, such as a device toaid in the delivery of the composition and/or instructions for makingthe composition or administration to a patient in need thereof.

Methods of making the present compositions are also provided herein.

DETAILED DESCRIPTION

The present inventor has discovered microparticle therapy compositionsthat include essential oils, such as Generally Recognized as Safe (GRAS)essential oils, herbs, and/or supplements, which advantageously killinfections, such as drug-resistant, drug-persisters, biofilms, and cystforms of infections. Essential oils, herbs and supplements are made upof several compounds which makes it much more difficult for pathogens todevelop resistance to. The present formulations and compositions arebelieved to be superior in the treatment and/or prevention of, interalia, a coronavirus infection or tick-borne infections and disease, suchas drug-resistant forms. The present formulations and compositions arealso believed to effective in treatment and/or prevention of otherinfections and/or disease, including, but not limited to a coronavirus,such as COVID-19.

The aspects, advantages and/or other features of example embodiments ofthe present disclosure will become apparent to those skilled in the art,in view of the present detailed description. It should be apparent tothose skilled in the art that the described embodiments of the presentdisclosure provided herein are merely exemplary and illustrative and notlimiting. Numerous embodiments of modifications thereof are contemplatedas falling within the scope of the present disclosure and equivalentsthereto. Unless otherwise noted, technical terms are used according toconventional usage. Any publications mentioned in this specification areindicative of the level of those skilled in the art to which theinvention pertains and are incorporated by reference in their entirety.For example, certain of the references cited herein (including Low, W.L., C. Martin, D. J. Hill, and M. A. Kenward. “Antimicrobial Efficacy ofLiposome-Encapsulated Silver Ions and Tea Tree Oil against Pseudomonasaeruginosa, Staphylococcus aureus and Candida albicans.” Letters inApplied Microbiology 57, no. 1 (July 2013): 33-39.https://doi.org/10.1111/lam.12082 and Cui, Haiying, Wei Li, Changzhu Li,Saritporn Vittayapadung, and Lin Lin. “Liposome Containing Cinnamon Oilwith Antibacterial Activity against Methicillin-Resistant Staphylococcusaureus Biofilm.” Biofouling 32, no. 2 (2016): 215-25.https://doi.org/10.1080/08927014.2015.1134516, for example. Thesereferences include examples showing the process of forming essential oilmicroparticles and testing such microparticle remedies againstpathogens.

In describing example embodiments, specific terminology is employed forthe sake of clarity. However, the embodiments are not intended to belimited to this specific terminology.

As used herein, “a” or “an” may mean one or more. As used herein,“another” may mean at least a second or more. Furthermore, unlessotherwise required by context, singular terms include pluralities andplural terms include the singular.

As used herein, the terms “composition”, “therapeutic composition”, and“formulation” may be used interchangeably and refer to a combination ofelements that is presented together for a given purpose. Such terms arewell known to those of ordinary skill in the art.

As used herein, “an effective amount” refers to an amount of one or moreactive ingredients in a composition, or an amount of the overallcomposition that is effective in attaining desired results, the purposefor which the constituent or composition is provided. Therefore, aneffective amount of a composition would be an amount suitable forachieving the desired effects in a subject, such as a mammal (e.g.,human) to which the present composition is administered. Desired resultsor a desired effect may include for example, providing prevention orlessening the likelihood of being infected with an infection or ofcontracting a disease; or the desired effect may lessen the infection ordisease or symptoms thereof; or the desired effect may include lesseninglength of duration of the infection or disease or symptoms thereof.

As indicated above, the present disclosure relates generally tomicroparticle therapy compositions, kits including such compositions orcomponents thereof, methods of making such compositions, and methods oftreating a subject with the present microparticle compositions byadministering an effective amount of a composition to a subject in needthereof to treat one or more infections. The microparticles may be inliposome form. Other microparticles, including certain essential oilmicroparticles may be in the form of emulsions, nano-emulsions,nanoparticles, nanostructured lipid carriers, etc., and may notnecessarily be for example, in liposome or other forms as discussedfurther herein.

By way of non-limiting example, the present microparticle therapies, ortherapy compositions, may include a liposome, nanoparticle,nanostructured lipid carriers (NLCs), or nano-emulsion composition thatincludes one or more of the following: GRAS (generally recognized assafe) essential oils, herbs, and supplements, including those presentlyavailable, as well as those that maybe identified and become availablein the future. According to non-limiting example embodiments, thepresent compositions may be formulated in amount and type ofingredients, based on the present inventor's discoveries, to achieve thedesired advantageous results discovered by the present inventor. TheFood and Drug Administration (FDA) has classified hundreds of essentialoils, herbs, and supplements as Generally Recognized as Safe (GRAS) forinternal consumption. Accordingly, those skilled in the art would beable to determine which essential oils, herbs, and supplements are GRASnow and at a future time, as additional essential oils, herbs andsupplements may be determined to be GRAS for internal consumption in thefuture.

Essential oils that may be used in accordance with the present inventioninclude those mentioned herein, as well as other essential oils that maybe used as a therapy or treatment for an illness or disease whenmodified to be in microparticle form. Non-limiting examples of essentialoils that may be used in accordance with embodiments of the presentinvention include the following:

ESSENTIAL OIL, SYNONYMS (botanical name(s)) African bluegrass(Cymbopogon validus) Agarwood (Aquilaria agallocha Roxb., Agallochummalaccense (Lamk) Kuntze, Aquilariella malaccensis) Ajowan(Trachyspermum ammi L., Carum copticum L.) Almond (bitter, FFPA)Botanical name: Prunus dulcis (Mill.) var. amara, Prunus communis L.var. amara, Prunus amygdalus, Batsch. var. amara, Amydalus communis L.var. amara, Amygdalus dulcis Ambrette seed, musk seed (Abelmoschusmoschatus Medik., Hibiscus abelmoschus L.) Amyris (Amyris balsamiferaL.) Angelica root (Angelica archangelica L., Angelica glauca Edgew.)Angelica seed (Angelica archangelica L., Angelica glauca Edgew.) Aniseseed (Pimpinella anisum L.) Anise star (Illicium verum J. D. Hook.)Artemisia annua (Artemisia annua L.) Asafoetida (Ferula asa-foetida L.)Atractylis, Cang-zhu, atractylodes (Atractylodes lancea (Thunb.) DC)Bakul, Bakula, vakul, vakul (Mimusops elengi L.) Balsamite, Costmary,alecost (Chrysanthemum balsamita L., Balsamita major Desf., Pyrethrummajus Desf.) Balsam poplar, tacamahac, black poplar (Populus balsamiferaL.) Basil (Ocimum basilicum L.) Basil holy, Sacred basil, tulsi (Ocimumtenuiflorum L., Ocimum sanctum L.) Basil Madagascan, Romba, ramy (Ocimumgratissimum L., Ocimum viride Willd.) Bay West Indian, (Pimenta racemosavar. racemosa (Miller) J. Moore, Pimenta acris Wight) Benzoin, GumBenjamin (Styrax benzoin Dryand, Styrax paralleloneurus Perkins Styraxtonkinensis Pierre) Bergamot FCF, Rectified bergamot,furanocoumarin-free bergamot (Citrus bergamia Risso & Poit., Citrusaurantium subsp. bergamia Risso & Poit.) Birch sweet, Black birch,cherry birch, mahogany birch, southern birch (Betula lenta L.) Blackseed, Black cumin, black caraway, Roman coriander, fennel flower, nutmegflower (Nigella sativa L.) Cajuput, Cajeput, cajaput, river tea tree,swamp tea tree, weeping tea tree, punk tree (Melaleuca cajuputi Powell,Melaleuca leucadendron var. cajuputi Roxb.) Calamus diploid form, NorthAmerican calamus, sweet flag (Acorus calamus L. var. americanus Raf.Wulff) Camphor white, Hon-sho true camphor (Cinnamomum camphora L.)Cananga (Cananga odorata Lam. J. D. Hook and T. Thompson f. macrophyllaKoolhaas, Canangium odoratum f. macrophylla) Cangerana (Cabraleacangerana Saldanha, Cabralea canjerana Saldanha) Caraway (Carum carviL.) Cardamon (Elettaria cardamomum L.) Carrot seed (Daucus carota L.subsp. sativus Hoffm.) Cascarilla, sweet-wood (Croton eluteria L. Sw.Bahamas, Croton reflexifolius Homb., Bonpl. & Kunth El Salvador) Cassia,Chinese or false cinnamon (Cinnamomum cassia Blume, Cinnamomumaromaticum Nees) Cedarwood Atlas, Atlantic cedar, Moroccan cedar (Cedrusatlantica G. Manetti) Cedarwood Himalayan, Deodar cedarwood (Cedrusdeodara Roxb. Ex D. Don) Cedarwood Texan, Mexican cedar, Mexicanjuniper, mountain cedar, rock cedar (Juniperus ashei Buchholz, Botanicalsynonym: Juniperus mexicana Spreng.) Cedarwood Virginian, Red cedar,Eastern red cedar (Juniperus virginiana L.) Celery leaf (Apiumgraveolens L.) Celery seed (Apium graveolens L.) Chamomile blue, Germanchamomile, Hungarian chamomile, sweet false chamomile (Matricariarecutita L., Chamomilla recutita L. Rauschert, Matricaria chamomilla L.)Chamomile Roman, (Chamaemelum nobile L. All., Anthemis nobilis L.)Champaca orange, Golden champa, champak (Michelia champaca L.) Chastetree, Monk's pepper (Vitex agnus castus L.) Cinnamon bark (Cinnamomumverum J. Presl., Cinnamomum zeylanicum Blume) Cinnamon leaf (Cinnamomumverum J. Presl., Cinnamomum zeylanicum Blume) Cistus (Cistus ladaniferL., Cistus ladaniferus Curtis) Citronella (Cymbopogon nardus L. synonym:Andropogon nardus L., Sri Lanka type citronella; Cymbopogon winterianusJowitt Java type citronella) Clary sage, Muscatel sage (Salvia sclareaL.) Clove bud (Syzygium aromaticum L. Merill et L. M. Perry, Eugeniacaryophyllata Thunb., Eugenia aromatica L.) Clove leaf (Syzygiumaromaticum (L.) Merill et L. M. Perry, Eugenia caryophyllata Thunb.,Eugenia aromatica L.) Clove stem (Syzygium aromaticum (L.) Merill et L.M. Perry, Eugenia caryophyllata Thunb., Eugenia aromatica L.) Copaiba(Copaifera langsdorfii Desf., Copaifera officinalis Jacq. L.) Corianderleaf, Cilantro (Coriandrum sativum L.) Coriander seed, Cilantro(Coriandrum sativum L.) Cubeb, Java pepper, tailed pepper, false pepper(Piper cubeba L.) Cumin (Cuminum cyminum L.) Cypress, Italian cypress,Mediterranean cypress (Cupressus sempervirens L.) Davana (Artemisiapallens Wall ex DC) Dill seed European (Anethum graveolens L.) Elemi(Canarium luzonicum Blume A. Gray, Canarium vulgare Leenh., Canariumcommune auct.) Eucalyptus (Eucalyptus camaldulensis Dehnh., Eucalyptusglobulus Labill. blue gum, Tasmanian blue gum; Eucalyptus maidenii F.Muell. Maiden's gum; Eucalyptus plenissima Gardner Brooker, Eucalyptuskochii subsp. plenissima Gardner; Eucalyptus polybractea R. T. Bakerblue-leaved mallee; Eucalyptus radiata Sieber ex DC, EucalyptusAustraliana R. T. Baker, Eucalyptus phellandra R. T. Baker,narrow-leaved peppermint, grey peppermint); Eucalyptus smithii R. T.Baker, gully gum, gully peppermint, blackbutt peppermint) Eucalyptusmacarthurii, Woolly butt, Camden woollybut, Paddy's river box(Eucalyptus macarthurii H. Deane & Maiden) Eucalyptus peppermint,Broad-leaved peppermint, blue peppermint, peppermint gum (Eucalyptusdives Schauer in Walp.) Fennel (Foeniculum vulgare Mill.) Feverfew,,Nosebleed, midsummer daisy (Tanacetum parthenium (L.) Sch. Bip.,Chrysanthemum parthenium (L.) Bernh.) Fir Douglas (Pseudotsuga menziesii(Mirbel) Franco) Fir cones silver, White fir, silver spruce, templin(Abies alba Mill.) Fir needle Canadian, Balsam fir, fir balsam (Abiesbalsamea L.) Fir needle Himalayan, East Himalayan fir, Himalayan silverfir (Abies spectabilis (D. Don) Spach, Abies webbiana (Wall ex D. Don)Lindl., Pinus spectabilis D. Don, Pinus webbiana Wall ex D. Don) Firneedle Japanese, Japanese pine needle, sachalin fir (Abies sachalinensisF. W. Schmidt) Fir needle Siberian, Russian fir, Siberian silver fir,Siberian pine needle (Abies sibirica Ledeb.) Fir needles silver, Whitefir, silver spruce, templin (Abies alba Mill.) Frankincense, Olibanum(Boswellia frereana Birdwood (synonym: Boswellia hildebrandtii Engl.)(African elemi, elemi frankincense); Boswellia papyrifera (Del.) Hochst(synonyms: Amyris papyrifera, Boswellia chariensis, Boswelliaoccidentalis, Boswellia odorata, Ploesslea floribunda) Sudanesefrankincense; Boswellia sacra Flueck. (synonyms: Boswellia carteriBirdwood, Boswellia bhau-dajiana Birdwood, Boswellia undulatocrenata)Saudi frankincense; Boswellia serrata Roxb. (synonyms: Boswellia glabraRoxb., Boswellia thurifera Roxb., Chloroxylon dupada) Indianfrankicnese; Boswellia neglecta S. Moore (‘Borena’ type frankincense);Boswellia rivae Engl. (‘Ogaden’ type frankincense)) Galangal greater,Siamese ginger (Alpinia galanga L., Amomum galanga L., Languas vulgareKoenig., Languas galanga L.) Galbanum (Ferula galbaniflua Boiss. &Buhse, Ferula gummosa Boiss., Ferula erubescens Boiss.) Garlic (Alliumsativum L.) Geranium (Pelargonium × asperum) Ginger (Zingiberofficinale) Gingergrass, Russa grass, sofia (Cymbopogon martinii,Andropogon martinii) Ginger lily, White ginger lily, butterfly lily,(Hedychium coronarium) Grapefruit (Citrus × paradisi Macfady) Hemp,Cannabis (Cannabis sativa L., Cannabis indica L.) Hibawood, Hiba, falsearborvitae (Thujopsis dolobrata) Hinoki leaf (Chamaecyparis obtusa(Siebold & Zucc.) Endl. var. obtusa, Cupressus obtusa) Hinoki root(Chamaecyparis obtusa (Siebold & Zucc.) Endl. var. obtusa, Cupressusobtusa) Hinoki wood (Chamaecyparis obtusa (Siebold & Zucc.) Endl. var.obtusa, Cupressus obtusa) Ho leaf, Hon-sho, true camphor tree(Cinnamomum camphora L.) Honeysuckle (Lonicera periclymenum L and otherLonicera species such as L. caprifolium L. and L. etrusca Santi) Hop,Common hop (Humulus lupulus L.) Hyssop (Hyssopus officinalis L. var.decumbens Briq.) Immortelle, Everlasting, helichrysum, curry plant(Helichrysum italicum (Roth) G. Don (synonym: Helichrysum angustifolium(Lam.) DC; Helichrysum stoechas L. subsp. stoechas) Inula, Sweet inula,camphor inula (Dittrichia graveolens (L.) Greuter, Inula graveolens (L.)Desf.) Jasmine, Royal jasmine, Spanish jasmine (Jasminum grandiflorumL., Jasminum officinale L. var. grandiflorum L., Jasminum officinale L.f. grandiflorum L.) Jasmine sambac, Arabian jasmine (Jasminum sambac L.)Juniperberry, Juniper (Juniperus communis L.) Juniper Phoenician,Phoenician savin (Juniperus phoenicea L.) Kanuka, White tea tree, burgan(Kunzea ericoides (A. Rich.) Joy Thomp., Kunzea peduncularis F. Muell.,Leptospermum ericoides A. Rich) Labdanum, Cistus ladanifer L. (Cistusladaniferus Curtis) Lantana (Lantana camara L.) Larch needle, Americanlarch, larch tamarack, hackmatack (Larix laricina Du Roi) Laurel berry(Laurus nobilis L., Laurus novocanariensis (previously Laurus azorica))Laurel leaf, Bay leaf, bay laurel, sweet bay (Laurus nobilis L.)Lavandin (Lavandula × intermedia Emeric ex Loisel., Lavandula hybridaReverchon, Lavandula hortensis Hy) Lavender, Common lavender, Englishlavender (Lavandula angustifolia Mill., Lavandula officinalis Chaix inVillars, Lavandula vera DC) Lavender Spanish, French lavender, maritimelavender (Lavandula stoechas L. ssp. stoechas) Lavender spike, Spike(Lavandula latifolia Medic., Lavandula spica DC) Leek (Allium porrum L.)Lemon balm Australian, Lemon-scented ironbark (Eucalyptus staigeriana F.v. Muell. ex F. M. Bailey) Lemon (Citrus × limon L., Citrus limonumRisso) Lemongrass (Cymbopogon flexuosus Nees ex Steud. (synonym:Andropogon flexuosus Nees ex Steud.) (East Indian); Cymbopogon citratusDC (synonym: Andropogon citratus DC) (West Indian)) Lemon-scented gum,Eucalyptus citriodora, lemon-scented iron gum, spotted gum, lemoneucalyptus (Corymbia citriodora Hook., Eucalyptus citriodora Hook.,Eucalyptus maculata Hook. var. citriodora Hook., Eucalyptus melissiodoraLindley) Lime, West Indian lime, Key lime, Lime Tahiti (Citrus ×latifolia Tanaka, Citrus × aurantifolia Christm.) Linaloe wood (Burseraglabrifolia Humb. (synonym: Bursera delpechiana Poisson) and otherBursera species such as B. aloexylon Schiede, B. fagaroides Humb., B.penicillata Sesse & Moc. and B. simaruba L)) Longoza, Longozo (Hedychiumcoronarium) Lovage leaf (Levisticum officinale W. S. Koch) Lovage root(Levisticum officinale) Lovage seed (Levisticum officinale) Mace(Myristica fragrans Houtt., Myristica officinalis L. fil., Myristicamoschata, Thunb., Myristica aromatica O. Schwartz, Myristica amboinensisGand.) Magnolia flower, White champaca, white jade orchid (Michelia albaDC, Michelia longifolia Blume, Sampacca longifolia (Blume) Kuntze)Magnolia leaf, White champaca, white jade orchid (Michelia alba DC,Michelia longifolia Blume, Sampacca longifolia (Blume) Kuntze) Mandarin,Common mandarin (Citrus reticulata Blanco, Citrus nobilis Andrews)Mandarin leaf, Mandarin petitgrain, petitgrain mandarin (Citrusreticulata Blanco, Citrus nobilis Andrews) Mango ginger (Curcuma amadaRoxb.) Manuka (Leptospermum scoparium J. R. Forster & G. Forster)Maraba, False galangal, false ginger, small galangal, resurrection lily(Kaempferia galanga L.) Marjoram Spanish, Mastic thyme, Spanish wildmarjoram (Thymus mastichina L. ssp. mastichina) Marjoram sweet (Origanummajorana L., Botanical synonyms: Majorana hortensis Moench, Origanumdubium Boiss.) Massoia (Cryptocarya massoy (Oken) Kosterm., Cryptocariamassoia (Becc.) Kosterm., Massoia aromatica Becc.) Mastic (Pistacialentiscus L.) May chang, Pheasant pepper tree (Litsea cubeba (Lour.)Pers., Litsea citrata Blume, Laurus cubeba Lour) Melissa, Balm, lemonbalm (Melissa officinalis L.) Mimosa (Acacia dealbata Link, Acaciadecurrens Willd. var. dealbata (Link) Muller, Racosperma dealbatum(Link) Pedley) Mint bergamot (Mentha aquatica L. var. citrata (Her.)Fresen, Mentha citrata Ehrh.) Mint wild forest, Common horsemint common(Mentha longifolia L.) Mugwort common, camphor/thujone CT, Mugwort,Indian wormwood (Artemisia vulgaris L.) Mugwort Douglas, Douglassagewort, California mugwort (Artemisia douglasiana Bess.) Mugwort great(Artemisia arborescens L.) Muhuhu (Brachylaena huillensis O. Hoffm.,Brachylaena hutchinsii Hutch.) Myrrh, Somalian myrrh (Commiphora myrrha(Nees) Engl., Commiphora molmol Engl.) Myrtle (Myrtus communis L.)Myrtle aniseed, Anise-scented myrtle (Backhousia anisata Vickery) Myrtlehoney, Marsh honey myrtle (Melaleuca teretifolia Endl.) Myrtle lemon,Lemon-scented myrtle, lemon ironwood, sweet verbena tree (Backhousiacitriodora F. Muell.) Nagarmotha, Cypriol, cyperus (Cyperus mitis Seud.,Cyperus scariosus R. Br.) Narcissus, Poet's narcissus (Narcissuspoeticus L.) Nasturtium, Indian cress (Tropaeolum majus L.) Neroli,Orange blossom (Citrus × aurantium L.) Niaouli (Melaleuca quinquenerviaCav.) Nut grass, Coco grass, motha (Cyperus rotundus L.) Nutmeg(Myristica fragrans Houtt., Myristica officinalis L. fil., Myristicamoschata Thunb., Myristica aromatica O. Schwartz, Myristica amboinensisGand.) Onion (Allium cepa L.) Opopanax, Opoponax, scented myrrh, sweetmyrrh, bisabol myrrh (Commiphora guidottii Chiov.) Orange, Sevilleorange (Citrus sinensis L., Citrus aurantium L. var. sinensis, Citrus ×aurantium L., tanical synonyms: Citrus aurantium L. subsp. amara L.,Citrus aurantium L. subsp. aurantium) Orange flower (Citrus sinensis L.,Citrus aurantium L. var. sinensis, Citrus × aurantium L., tanicalsynonyms: Citrus aurantium L. subsp. amara L., Citrus aurantium L.subsp. aurantium) Orange leaf, Petitgrain, orange petitgrain, bitterorange leaf, sour orange leaf, Seville orange leaf (Citrus × aurantiumL.) Oregano, Origanum (Origanum syriacus L., Origanum onites L.(synonym: Origanum smyrnaeum L.); Origanum vulgare L. subsp. hirtum(Link) letswaart (synonyms: Origanum compactum, Origanum hirtum Link);Thymbra capitata (L.) Cav. (synonyms: Thymus capitatus L., Coridothymuscapitatus L., Satureja capitata L.); and occasionally other Origanumspecies) Oregano Mexican (Lippia graveolens HBK, Lippia berlandieriSchauer, Lippia amentacea M. E. Jones, Lippia tomentosa Sessé & Moc.)Orris, Iris (Iris pallida Lam., Iris × germanica L.) Osmanthus, Fragrantolive, sweet olive, tea olive (Osmanthus fragrans Lour., Olea fragransThunb.) Palmarosa, Motia, rosha grass (Cymbopogon martinii Roxb. var.martinii, Andropogon martinii Roxb. var martinii, Cymbopogon martiniiRoxb. var. motia) Palo santo (Bursera graveolens (Kunth) Triana etPlanch) Parsley leaf, Parsley herb (Petroselinum crispum Mill.,Petroselinum sativum Hoffm., Petroselinum hortense auct.) Parsley seed(Petroselinum crispum Mill., Petroselinum sativum Hoffm., Petroselinumhortense auct.) Parsnip (Pastinaca sativa L.) Patchouli (Pogostemoncablin (Blanco) Benth., Pogostemon patchouly Pellet) Pepper (Pipernigrum L.) Pepper pink, California pepper, Peruvian pepper, Peruvianmastic (Schinus molle L.) Pepper Sichuan, Japanese pepper, fagara,prickly ash, hua jiao (Zanthoxylum piperitum DC) Peppermint (Mentha ×piperita L.) Perilla, Beefsteak plant, shiso (Perilla frutescens (L.)Britt.) Peru balsam (Myroxylon balsamum (L.) Harms var. pereirae (Royle)Harms, Myroxylon pereirae Royle; Myroxylon peruiferum L. F. Myrospermumpereirae Royle; Toluifera pereirae Royle) Peta (Helichrysum splendidumLess.) Phoebe (Phoebe porosa Mez., Oreodaphne porosa Nees ex Mart)Pimento leaf, Pimenta leaf (Pimenta dioica L., Pimenta officinalisLindl.) Pine black (Pinus nigra J. F. X Arnold) Pine dwarf, Mountainpine, dwarf mountain pine, mugo pine, pumilio pine (Pinus mugo Turra(synonym: Pinus Montana Mill.); Pinus mugo Turra var. pumilio Haenke(synonym: Pinus pumilio Haenke); Pinus mugo Turra var. mugo Zenari(synonym: Pinus mugus Scop.)) Pine grey, Jack pine (Pinus divaricataAlton, Pinus banksiana Lamb.) Pine ponderosa, Western yellow pine (Pinusponderosa Douglas ex P. Lawson & C. Lawson) Pine, Scotch pine (Pinussylvestris L.) Pine white (Pinus strobus L.) Piri-piri, Jointed flatsedge, priprioca, adrue (Cyperus articulatus L.) Plai (Zingiber montanum(J. König) Theilade, Amomum montanum J. König, Zingiber cassumunarRoxb.; Zingiber purpureum Roscoe) Plectranthus (Plectranthus fruticosusL'Hérit.) Rambiazana, Rambiazinza vavy (Helichrysum gymnocephalumHumbert) Ravensara bark, Havozo (Ravensara aromatica Sonnerat, Ravensaraanisata Danguy et Choux) Ravensara leaf (Ravensara aromatica Sonnerat,Ravensara anisata Danguy et Choux) Rhododendron, Anthopogon, sunpati(Rhododendron anthopogon D. Don.) Rosalina, Lavender tea tree, Swamppaperbark tree (Melaleuca ericifolia Smith) Rose Damask, Rose otto (Rosa× damascena Mill., Rosa damascena Mill. var. trigintipetala (Dieck)Koehne; Rosa gallica f. trigintipetala Dieck) Rose Japanese, Ramanasrose, rugosa rose (Rosa rugosa Thunb.) Rose Provence, Cabbage rose, rosede Mai, French rose, hundred-leaved rose (Rosa × centifolia L., Rosagallica L. var. centifolia (Regel.)) Rosemary (Rosmarinus officinalisL.) Rosewood, Bois de rose, Pau-rosa (Aniba rosaeodora Ducke, Anibaamazonica Ducke, Aniba parviflora Meissner Mez.) Saffron (Crocus sativusL.) Sage blue mountain, Stenophylla (Salvia stenophylla Burch, exBenth.) Sage Greek, Turkish sage (Salvia fruticosa Mill., Salvia trilobaL.) Sage Spanish, Lavender sage (Salvia lavandulifolia Vahl., Salviahispanorum Lag.) Sage white (Salvia apiana Jeps.) Sage wild mountain,Mountain salvia (Hemizyqia petiolata Ashby) St. John's wort (Hypericumperforatum L.) Sandalwood East African (Osyris lanceolata Hochst. &Steud.; Osyris tenuifolia Engl.) Sandalwood New Caledonian, Pacificisland sandalwood (Santalum austrocaledonicum Vieill.) SandalwoodWestern Australian (Santalum spicatum A. DC., Santalum cygnorum Miq;Fusanus spicatus R. Br.; Eucarya spicata Sprag, et Summ.) Sanna, Spikedginger lily, kapur kachri (Hedychium spicatum Sm.) Saro, Mandravasarotra(Cinnamosma fragrans Baill.) Satsuma, Mikan (Citrus unshiu Marc., Citrusreticulata Blanco var. satsuma) Savory (Satureia hortensis L. (summersavory); Satureia montana L. (winter savory)) Southernwood (Artemisiaabrotanum L.) Spearmint (Mentha cardiaca G. (Scotch spearmint); Menthaspicata L. var. crispa (Bentham) Danert (native spearmint), Menthacrispa L., Mentha viridis L. (native spearmint)) Spruce black, Canadianblack ‘pine’ (Picea mariana (Mill.) Britton, Picea nigra Link) Sprucehemlock, Eastern hemlock, hemlock (Tsuga Canadensis (L.) Carrière, Pinuscanadensis L., Picea canadensis L.) Spruce Norway, Common spruce,European spruce (Picea abies L., Picea excelsa Link) Spruce red (Picearubens Sarg.) Spruce white, Canadian spruce (Picea glauca (Moench) Voss,Picea alba Link, Picea canadensis Mill.) Styrax, Storax, sweetgum(Liquidambar orientalis Mill. (Asian styrax), Liquidambar styraciflua L.var macrophylla (American styrax)) Sweet vernalgrass, Flouve(Anthoxanthum odoratum L.) Taget, Marigold, tagetes (Tagetes minuta L.(synonym: Tagetes glandulifera Schrank), Tagetes patula L.) Tana, Issa(Rhus taratana (Baker) H. Perrier) Tangelo (Citrus reticulata Blanco ×Citrus × paradisi Macfady) Tangerine (Citrus reticulata Blanco, Citrusnobilis Andrews, Citrus tangerine Hort. ex Tanaka) Tansy (Tanacetumvulgare L., Chrysanthemum tanacetum Karsch, Chrysanthemum vulgare L.)Tansy blue, Moroccan Tansy, Moroccan blue chamomile (Tanacetum annuumL.) Tea leaf, Black tea (Camellia sinensis L., Thea sinensis L.) Teatree (Melaleuca alternifolia Cheel (syn. Melaleuca linariifolia var.alternifolia Maid. & Bet.)) Tea tree black, River tea tree oil(Melaleuca bracteata F. von Müller) Tea tree lemon-scented, Lemon teatree (Leptospermum petersonii F. M. Bailey (syn: Leptospermum citratumChalk, Cheel & Pent.); Leptospermum liversidgei R. T. Baker & H. G.Smith) Tejpat, Indian cassia (Cinnamomum tamala Buch.-Ham.) Thyme,Moroccan thyme, thyme spike (Thymus vulgaris L., Thymus satureioidesCoss. & Bal., Thymus zygis L., Thymbra spicata L.) Thyme lemon (Thymus ×citriodorus (Pers.) Schreb., Thymus lanuginosus Mill. var. citriodorumPers., Thymus serpyllum var. citriodorus (Hort.), Thymus serpyllum L.var. vulgaris Benth.) Tolu balsam, Thomas balsam, opobalsam (Myroxylonbalsamum (L.) Harms var. balsamum) Tonka (Dipteryx odorata (Aubl.)Willd., Coumarouna odorata Aubl.) Turmeric leaf (Curcuma longa L.)Turmeric rhizome, Indian saffron (Curcuma longa L., Curcuma domesticaVai., Curcuma aromatica Salisb.) Valerian European type (Valerianaofficinalis L., Valeriana fauriei Briq.) Valerian Indian, Sugandhawal(Valeriana jatamansi Jones, Nardostachys jatamansi (D. Don) DC;Valeriana wallichii DC, Fedia grandiflora Wall.; Patrinia jatamansi(Jones) D. Don) Vanilla (Vanilla planifolia Andr. (synonym: Vanillafragrans Salisb.) (Bourbon vanilla); Vanilla tahitensis J. W. Moore(Tahitian vanilla)) Verbena honey, Wild verbena, greendog, zinziba(Lippia javanica Spreng.) Verbena lemon, Verbena (Aloysia triphyllaL'Hérit., Aloysia citriodora Ortega ex Pers., Lippia citriodora Ortegaex Pers., Lippia triphylla L'Hérit., Lippia alba (Mill.) N. E. Brown)Vetiver, Khus, khus-khus (Vetiveria zizanoides (L.) Nash, Andropogonmuricatus (Retz.), Andropogon zizanoides (L.) Urban, Chrysopogonzizanoides (L.) Roberty, Phalaris zizanoides L.) Wintergreen (Gaultheriafragrantissima Wall.; Gaultheria procumbens L.) Wormwood, Absinthe,artemisia (Artemisia absinthium L.) Wormwood annual, Sweet wormwood,sweet annie (Artemisia annua L.) Yarrow, Milfoil (Achillea millefoliumL.) Ylang-ylang (Cananga odorata J. D. Hook. & T. Thompson f. odorata,Cananga odorata J. D. Hook. & T. Thompson f. genuina) Yuzu (Citrus junosSieb. ex Tanaka.) Zedoary, White turmeric, hidden ginger (Curcumazedoaria Roscoe)

Herbs that may be used in accordance with the present invention includethose mentioned herein, as well as other herbs that may be used as atherapy or treatment for an illness or disease when modified to be inmicroparticle form_Non-limiting examples of herbs that may be used inaccordance with embodiments of the present invention include thefollowing:

Achyrantis (Radix Achryranthis Bidentatae) Aconite (AconitumKusnezoffii, Aconitum spp.) Acorus (acorus calmus, Rhizoma AcoriTatarinowii ) Agaricus mushroom Agarikon mushroom Agimony (HerbaAgrimoniae) Akebia (Caulis Akebiae) Alisma (Rhizoma Alismatis) Amomum(Fructus Amomi) Andrographis Angelica dahuricae radix Angelica sinensisradix Artemisia annua L. Artemisia argyii folium Ashwagandha Asparagusroot (Radix Asparagi) Astragalus root Bamboo sap (Caulis Bambusa inTaenia) Basil leaf Belamcanda (Belamcanda Chinensis Rhizome) Bittermelon Bacopa monniera Black walnut hull Bauhinia tormentosa Burdock rootCascara sagada Cats claw Centella asiatica Chaga mushroom Chrysanthemumflower (Flos Chrysanthemi) Lovage root (Chuanxiong Rhizoma) Cimcifuga(Rhizoma Cimcifugae) Cinnamon bark Cinnamon twig (Cinnamomi Ramulus)Cistus incanus Citrus seed (Semen Citri Reticulatae) ClerodendrumTrichotomum Club moss Clove bud Cnidium Coptis Chinensis Cordycepsmushroom, Cornus (Cornus Officalis Fructus) Corydalis (CorydalisRhizome) Curcuma root (Curcuma Phaeocaulis Radix) Cynomorus (HerbaCynomorii) Cyperus (Rhizoma Cyperi) Cortex Lycii Crataegus (FructusCrataegi) Curcurmae Rhizoma Cyanchi (Radix et Rhizoma CyanchiPaniculati) Dandelion root Deer antler (Cornu Cervi Pantotrichum)Dichroae Radix Dioscorea root (Rhizoma Dioscoreae) Dipsacus (DipsaciRadix) Dragon bone (Os Draconis) Dryopteridis (Cyrtomii Rhizoma)Echinacea purpurea Eclipta (Ecliptae Prostratae Herba) Eleuthero rootElsholtzia (Elsholtziae Splendentis Herba) Epimedium leaf Eribotrya leaf(Eriobotryae Japanicae Folium) Eucommia (Cortex Eucommiae) Evodia(Evodia Rutaecarpa Frctus) Fenugreek seed Forsythia fruit Frankincense(Gummi Olibanum) Fritillaria (Fritillaria Thungbergii Bulb) FructusJujubae Fructus Psorleae Fructus Toosendan Fructus Tsaoko Chinese nutgall (Galla Chinensis) Gardenia (Gardenia Jasminoides Fructus) Gastrodia(Rhizoma Gastrodiae) Gentiana Macrophyla root (Gentiana MacrophyllaeRadix) Gentiana scabra root (Gentiana Scabra Radix) Ginger root(Zingiberis Recens Rhizoma) Ginseng root (Ginseng Radix et Rhizoma)Gynostemma (Gynostemma Fructus) Gypsum (Gypsum Fibrosum) He Shou Wu,Fo-Ti (Polygonum Multiflorum Radix) Herba cum radice patriniae HerbaMenthae Herba Scutellariae Barbarate Honeysuckle flower (LoniceraJaponica Flos) Honeysuckle vine (Lonicera Japonica Caulis) Houttuynia(Houttuyniae Herba) Indigo (Indiogofera Tinctoria L.) Isatis leaf(Baphicacanthus Folium) Isatis root Jave brucea fruit Kudzu rootLicorice root (Radix Glycyrrhiza glabra) Ligustrum (Fructus LigustriLucidi) Lily bulb Lindera (Radix Linderae) Lions mane mushroomLithospermum (Arnebia Euchroma Radix) Longan fruit (Arillus Longan)Lotus rhizome (Nodus Nelumbinis Rhizomatis) Lycii berries Lycopus(Lycopus Lucidus Herba) Magnetitum Magnolia Bark (Magnolia OfficianlisBark) Magnolia flower (Magnolia Officianlis Flos) Maitake mushroom Milkthistle Mimosa pudica Mistletoe Mucuna puriens Mulberry fruit (FructusMori) Mulberry leaf (Morus Alba Folium) Mulberry twig (Morus AlbaRamulus) Myrrh (Commiphora Myrrha) Neem leaf Nettle leaf Prunella (SpicaPrunellae) Pseudoginseng, notoginseng (Notoginseng Radix et Rhizoma)Nutmeg (Semen Myristicae) Olive leaf Oldenalndia (Oldenalndia diffusa)Ophiopogon (Radix Ophiopogonis) Oregon grape root Osha root (LigusticumPor. Osha) Oyster shell (Ostrea Gigas) Patchouli (Pogostemon CablinHerba) Peach kernel (Semen Persicae) White peony root (Peoniaelactiflora radix) Perilla (Perilla Folium) Phellodendron (PhellodendronRadix) Earthworm (Pheretima) Pineilia prepared Plantaginis Herba Pokeroot Polygala Polygonum (Polygoni Multiflori Caulis) Polygonatum Rhizome(Polygonati Rhizoma) Japanese Knotweed (Polygonum cuspidatae) Lysimachia(Herba Lysimachiae) Litchi seed (Semen Litchi) Platycodon root (RadixPlatycodonis) Poria fungus Poria Paradicis Privet fruit Quassia barkRadix Angelica Pubscentis Radix Atractylodis Macrocephalae, RadixAtractylodis Radix Cyanthulae Radix Glehniae Radix Peonae, Radix PeonaeRubrae Radix Puerariae Lobatae Radix Pulsatilla Rehmannia raw, cooked(Radix Rehmanniae) Radix Saposhnikoviae Radix Stephaniae TetrandraeRadix Vladimiriae Ramulus Uncariae cum Uncis Red sage, Chinese sage, tanshen, or danshen (Radix Salvia miltiorrhiza) Reishi mushroom Reishimushroom spores Rhizoma Alpiniae Officinarum Rhizoma Drynariae Rhodiolarosea Safflower (Flos Carthami) Sanguisorbia Officinalis RadixSchisandra berry (Schisandra Chinensis Fructus) Schizonepeta (HerbaSchizonepetae) Scrophularia Scutellaria root (Scutellariae Radix) SemenPlatycladi Shiitake mushroom Sida cordifolia Smilax (Smilacis GlabraeRhizome) Sophora flower(Sophora flavescens Flos) Sophora root (Sophoraflavescens Radix) Sour plum Spargani (Rhizoma Sparganii) Spatholobusroot, vine (Spatholobi Caulis) St. John's Wort Tangerine peel Taxilia(Herba Taxilli) Teasel root american Terminalia chebula Thunder god vineTree Peony (Moutan Radicis Cortex) Tribulus (Tribulus terrestrisFructus) Tricosanthis (Tricosanthes Kirlowii Radix) Turkey tail mushroomTurkey rhubarb (Rheum palmatum, Radix Rhizoma Rhei) Turmeric root(Curcuma longa) Verbena (Herba Verbenae) Viola (Viola Yedoensis Herba)Vitex (Vitex negundo)

Supplements that may be used in accordance with the present inventioninclude those mentioned herein, as well as other supplements that may beused as a therapy or treatment for an illness or disease when modifiedto be in microparticle form. Non-limiting examples of supplements thatmay be used in accordance with embodiments of the present inventioninclude the following:

Acacia fiber Benfotiamine Colloidal gold Colloidal silver CurcuminErythritol Glutamine Glutathione Glycerine Grapefruit seed extract Hempextract, CBD Huperzine Ionic silver Lysozyme Magnesium Monkfruit extractNAC Phosphatidylcholine Phosphatidylserine Potassium sorbate PropolisResveratrol Seawater, Quintons Sodium Butyrate Stevia leaf extractSunflower lecithin Vitamin C Xylitol

The present compositions may include one or more active substances (suchas essential oils, herbs and supplements), which are included to achievethe desired therapeutic effect, and may optionally also include one ormore excipients, such as a carrier, coating, binder, etc, as may bedetermined by those skilled in the art, so long as the therapeuticeffect is not compromised by virtue of the excipient(s).

The term “excipient” is used herein to include pharmaceuticallyacceptable inert substances added to a drug formulation or compositionto give e.g., a desired consistency or form, or used as a carrier.Non-limiting examples of excipients that may be included in the presentcompositions and/or formulations herein may include, but are not limitedto binders, fillers, diluents, lubricants, anti-infectious agents,antimicrobial agents and solubility modifiers, and other excipientsknown to those skilled in the art, depending e.g., on the compositionbeing formed, intended method of administration and/or method offormation, the active ingredient(s) being used, etc.

Non-limiting examples of the present invention include novel methods ofusing FDA GRAS microparticle compositions to treat infections, such astick infections, in humans and animals.

According to example embodiments, the present invention providesmicroparticle compositions that include one or more ingredients selectedfrom essential oils, herbs, and supplements, that have been modified orsynthesized to be in microparticle form. The one or more essential oils,herbs, and supplements in microparticle form are formulated to bepharmaceutically acceptable for administration in an effective amount toa subject, for treatment of an infection or disease in the subject. Innon-limiting example embodiments, the infection or disease is a Lymetick borne illness related infection or disease, or a coronavirus.

Non-limiting examples of infections that may be treated using thepresent compositions and methods may include bacterial, viral and/orfungal infections. By way of non-limiting example, the invention mayinclude one or more Lyme tick infections. Infections that may be treatedby the present compositions and methods may include for exampleBorrelia, Bartonella, Babesia, Ehrlichia, Anaplasmosis, Rickettsia,Mycoplasma, viruses, parasites, fungi, bacteria, and any other tickinfection. It is also contemplated that the infection may be acoronavirus infection, such as Covid-19.

By way of non-limiting example, the microparticle composition of thepresent invention may include one or more of the following ingredients:Carrot seed essential oil (EO), celery seed EO, cinnamon bark, clove budEO, German chamomile EO, copaiba EO, geranium EO, helichrysum EO,lemongrass EO, mountain savory EO, oregano EO, spearmint EO, organicsunflower lecithin, Roman chamomile EO, cardamom seed EO, cinnamon EO,lavender EO, lemon balm, thyme EO, organic sunflower lecithin, BergamotEO, hyssop EO, marjoram EO, nutmeg EO, petitgrain EO, and thyme EO. Itmay further include purified water. Compositions including thesecomponents may be used for example for the treatment of Lyme tick borneinfections, illness or disease.

By way of non-limiting example, the microparticle composition of thepresent invention may include one or more of the following ingredients:Bay Laurel EO, Eucalyptus globulus EO, organic sunflower lecithin, Herbahouttuyniae, Ganoderma, Folium isatidis, Radix scutellariae, Gallachinensis, Radix astragali, Radix et Rhizoma glycyrrhizae, Folium mori,Flos chrysanthemi, Flos lonicerae japonica, Fructus forsythia, Herbamoslae, Rhizoma zingiberis, and Folium eriobotryae. The composition mayfurther include purified water, such as reverse osmosis water.Compositions including these components may be used for example for thetreatment of coronovirus infections, illness or disease.

According to example embodiments, the one or more essential oils, herbs,and supplements, are modified or synthesized into one or moremicroparticle forms selected from liposomes, nanoparticles,nanostructured lipid carriers, and nano-emulsion compositions.

Methods of treatment in accordance with non-limiting example embodimentsof the present invention may include treating a subject/patient havingan infection with one or more of the present microparticle therapycompositions, by administering an effective amount of the composition(s)to a subject/patient in need of such treatment. According tonon-limiting example embodiments, it is contemplated that methods oftreatment may include treating a subject or patient who may not yet havean infection, as a preventative treatment. Non-limiting example methodsmay have one or more of the following effects to be consideredtreatment, lessening or eliminating the infection or disease or symptomsthereof, reducing the duration of the infection or disease, or symptomsthereof, and/or lessening or reducing the possibility of catching theinfection or disease.

Non-limiting example embodiments of the present invention includemethods of treating a subject having an infection or disease, such as aLyme tick borne illness related infection or disease or a coronavirusinfection, which include administering to the subject a microparticlecomposition provided herein. The microparticle compositions herein mayinclude one or more ingredients selected from essential oils, herbs, andsupplements, that have been modified or synthesized to be inmicroparticle form, in an effective amount to treat the Lyme tick borneillness related infection or disease or a coronavirus infection.

Appropriate methods of administration may include for example, oraladministration in a liquid, tablet, capsule, sublingual or other oralform, as would be known to those skilled in the art. For example,essential oils can be taken internally in liposomes, in a carrier oil,or in a suppository: sublingual, oral, nasal, otic, rectal, or vaginal.The target may be neurological, sinus, oral, respiratory, pelvic,systemic symptoms. Essential oils may also be applied externally, suchas topically, by laser remedy, or diffuse to target the respiratory,skin, joint, muscular and systemic symptoms. Other non-limiting methodsof administration, such as IV and injection methods are alsocontemplated as being suitable. In example embodiments, themicroparticle compositions of the present invention may be administeredto a subject by an administration method selected from orally, nasally,rectally, vaginally, topically, intravenously or by injection.

According to example methods, the one or more essential oils (EOs),herbs, and supplements; are modified into one or more microparticleforms selected from the group consisting of liposomes, nanoparticles,nanostructured lipid carriers, and nano-emulsion compositions.

According to non-limiting example embodiments, the infection or diseasemay be a Lyme tick-borne infection or disease, such as drug-resistantforms, drug-persisters, biofilms, cystic forms of tick infectionsincluding Borrelia, Bartonella, Babesia, Ehrlichia, Anaplasmosis,Rickettsia, Mycoplasma, viruses, parasites, fungi, bacteria, and anyother tick infection. It is also contemplated that the infection may bea coronavirus infection, such as Covid-19.

According to example embodiments, the formulation and treatment may becustom engineered to the patient depending on the patients underlyingissues.

The present therapies or compositions may be administered by any methoddeemed suitable by a physician or other individual skilled in the art.As indicated above, by way of non-limiting example, thecomposition/therapy may be administered orally, nasally, rectally,vaginally, topically intravenously or by injection.

As used herein, the term “recipient”, “subject” or “patient” is intendedto include any animal, such as a mammal (including, but not limited tohumans) to whom the present compositions may be administered. A subjector patient may or may not be under current medical care, and may or maynot have had one or more prior treatments. Although, as would beapparent to those skilled in the art, the formulations and dosages maybe different for non-humans than for humans, taking into considerationcertain requirements for safety for administration.

Appropriate dosages of the therapies or compositions provided herein maybe determined by those skilled in the art, depending on various factors,such as the severity of the infection or other ailment being treated,the weight of the subject, the type of infection or other ailment beingtreated, etc. Dosage amounts, frequency, and total number of doses, maybe adjusted to achieve desired affects, depending on for example, thesubject's/tolerance and reaction to previous doses (if any). A unitdosage may comprise a therapeutically effective amount of one or moreingredients. A unit dosage will depend upon many factors, which mayinclude for example, age, size, and condition of the individual beingtreated and the number of times the unit will be taken.

According to example embodiments, essential oils may be used fortargeting persistent lyme disease and co-infections. Anti-microbialessential oils may be used to fight or inhibit for example Borreliapersisters and chronic symptoms in reservoirs: brain, joints, insidecells, and under biofilms. The essential oils may also be used fortargeting coinfections, and/or for targeting relapsing symptoms.

According to non-limiting example embodiments, compositions ofmicroparticle essential oils may be effective to treat patients havingBartonella. In particular, microparticles of the following essentialoils may be used to treat Bartonella.

Carrot seed EO about 3-5% or about 4%, celery seed EO about 7-9% orabout 8%, cinnamon bark about 0.1-2% or about 1%, clove bud EO about0.1%-2%, or about 1%, German chamomile EO about 7-9% or about 8%,copaiba EO about 7-9% or about 8%, geranium EO about 3-5% or about 4%,helichrysum EO about 3-5% or about 4%, lemongrass EO about 12-14% orabout 13%, mountain savory EO about 3-5% or about 4%, oregano EO about4-6% or about 5% spearmint EO 3-5% or about 4%, organic sunflowerlecithin about 34-38% or about 36%. It should be apparent that some ofthese ingredients may be removed and/or others added. The microparticlesmay be prepared for example by combining the oils with sunflowerlecithin and reverse osmosis water in a 20K+ RPM high speed blender. Theresulting emulsion is poured into a glass container. The glass containeris placed in a 20-60 Khz ultrasound water bath for 30 minutes. Theresulting solution is approximately 80% essential oil liposomes and 20%essential oil emulsion.

According to other non-limiting example embodiments, compositions ofmicroparticle essential oils may be effective to treat patients havingBorrelia and/or Babesia. In particular, microparticles of the followingessential oils may be used to treat Borrelia and Babesia infections:Roman chamomile EO about 7-9%, or about 8%, cardamom seed EO about 1-3%or about 2%, cinnamon EO about 0.1-2% or about 1%, helichrysum EO about7-9% or about 8%, lavender EO about 7-9% or about 8%, lemon balm about3-5% or about 4%, thyme EO about 11-13% or about 12%, organic sunflowerlecithin about 35-39% or about 37%. As with other embodiments, it shouldbe apparent that some of these ingredients may be removed and/or othersadded, such as purified water (or reverse osmosis water). Themicroparticles may be prepared for example by sonication.

According to other non-limiting example embodiments, compositions ofmicroparticle essential oils may be effective to treat patients havingBorrelia. In particular, microparticles of the following essential oilsmay be used to treat Borrelia infections: Bergamot EO about 1.5-3.5% orabout 2.5%, carrot seed EO about 1.5%-3.5% or about 2.5%, Romanchamomile EO about 4-6% or about 5%, hyssop EO about 1.5-3.5% or about2.5%, lemongrass EO about 4-6% or about 5%, marjoram EO about 9-11% orabout 10%, nutmeg EO about 4-6% or about 5%, petitgrain EO about1.5-3.5% or about 2.5%, thyme EO about 9-11% or about 10%, organicsunflower lecithin about 60%-70%, or about 65%. As with otherembodiments, it should be apparent that some of these ingredients may beremoved and/or others added, such as purified water (or reverse osmosiswater). The microparticles may be prepared for example by sonication.

According to other non-limiting example embodiments, compositions ofmicroparticle essential oils may be effective to treat patients having acoronavirus, such as Covid-19. In particular, according to exampleembodiments, microparticles of the following essential oils may be usedto Covid-19 infections: Bay Laurel EO about 18-22%, or about 20%,Eucalyptus globulus EO about 13-17%, or about 15%, and organic sunflowerlecithin about 60-70%, or about 65%. As with other embodiments, itshould be apparent that some of these ingredients may be removed and/orothers, such as purified water (or reverse osmosis water), added. Themicroparticles may be prepared for example by sonication.

According to other example embodiments, microparticles of the followingessential oils may be used to Covid-19 infections: Herba houttuyniaeabout 7-9%, or about 8%, Ganoderma about 7-9% or about 8%, Foliumisatidis about 3-5% or about 4%, Radix scutellariae about 3-5% or about4%, Galla chinensis 3-5% or about 4%, Radix astragali about 3-5% orabout 4%, and Radix et Rhizoma glycyrrhizae about 2-4% or about 3%

Other herbs with anti-Covid-19 properties which may be included in theabove or other formulations used to treat patients with a Covid-19infection include Folium mori, Flos chrysanthemi, Flos loniceraejaponica, Fructus forsythia, and/or Herba moslae, Rhizoma zingiberis,and Folium eriobotryae.

Organic sunflower lecithin in an amount of about 60-70%, or about 65%may also be used for the treatment of Covid-19, with purified water suchas reverse osmosis water.

The present inventor discovered that microparticle essential oils mayresult in reducing Jarisch-Herxheimer reactions. Essential oils in labstudies were also shown to reduce Lyme disease persisters and theirbiofilms. Essential oils may be combined with antibiotics to enhancetreatment outcomes and reduce persisters.

Clove bud essential oil may be used e.g., to inhibit Borreliapersisters, Fusarium spp, Aspergillus spp., Aspergillus aflatoxin B 1,Candida, E. coli, Streptococcus spp., Staphylodoccus spp, MRSA, Giardia,or helminths.

Certain essential oils may be effective to treat Borrelia persisters.These essential oils include oregano, cinnamon bark, and clove bud,which completely eradicated all viable persister cells without anyregrowth in subculture in fresh medium. Other oils, such as citronelland wintergreen did not have this effect. Garlic, allspice, myrrh,hedycheim, and Litsea cubeba completely eradicated all B. burgdorferistationary phase cells at 0.1%. Other essential oils failed to do so, aswas shown by visible spirochetal growth.anti-malaria essential oils forBabesia include caraway (875 mg/day), nutmeg (28 mg/day) and myrtle (65mg/day).

Anti-Bartonella essential oils include clove bud. Anti-Mycoplasmaessential oils include tea tree and bergamot FCF. Anti-Brucellaessential oils include oregano oil and cinnamon bark (200 mg/day).

The present application further relates to methods of making the presentcompositions. “Microparticle” essential oil, herbal, and supplementtherapies may be advantageous in achieving reduced toxicity, the abilityto penetrate more deeply inside cells, biofilms, and tissues, andgreater antimicrobial efficacy compared to non-microparticle remedies.Non-limiting methods of making the present compositions may includecombining the one or more essential oils, herbs, and supplements; andmodifying the essential oils, herbs, and supplements into amicroparticle form.

As with other embodiments herein, in these embodiments, microparticlecompositions, therapies, or therapy compositions of the presentinvention, may include for example, liposome, nanoparticle,nanostructured lipid carriers (NLCs), or nano-emulsion composition.These microparticles can be produced via several methods, which mayinclude, but are not limited to the following methods that are presentlyknown or future methods to be developed.

-   -   1. Sonication uses high frequency ultrasound waves to break up        essential oils, herbs, and/or supplements into smaller        microparticles. These microparticles are in a solution of water        and a lipid or other biocompatible liposome coating. The coating        forms around the microparticles in the solution.    -   2. Methanol injection uses water that is poured into a        concentrated lipid-ethanol-essential oils, herbs, and/or        supplements solution, and then ethanol is removed in an        evaporator. Dilution with water causes spontaneous formation of        small and homogenous unilamellar vesicles from micellar        aggregate. The size of liposomes can be controlled by the ratio        of ethanol to water.    -   3. Freeze-thaw method uses a repeated freeze-thaw cycle of        freezing in liquid nitrogen at −196 degrees C. followed by        thawing at temperatures as high as 122 degrees F. produces        microparticle liposomes. In lab experiments, the freeze-thaw        method has produced optimal microparticles using as few as five        cycles.    -   4. French Pressure Cell method uses pressures as high as 20,000        PSI where aqueous suspensions of lipid and essential oils,        herbs, and supplements are placed within the chamber of a French        pressure cell at room temperature and rapidly extruded at 20,000        psi through a small orifice.

It is contemplated that other methods of forming microparticles may bedeveloped and would be included within the scope of the presentinvention.

According to example embodiments, combinations of desired essentialoils, herbs and other ingredients are combined, and thereafter formedinto microparticles (such as liposome, nanoparticle, nanostructuredlipid carriers (NLCs), or nano-emulsion composition), as describedherein, or as would be understood by those skilled in the art based onthe present disclosure.

The exact composition of a particular microparticle composition,formulated for use in the present invention, may vary, depending e.g.,the components to be used, the desired infection to be treated, theintended recipient, the method of administration (topical, oral, etc),and other factors indicated herein and/or known to those skilled in theart.

Sublingual Essential Oils (EOs) may be used for Relapsing symptoms. Innon-limiting example embodiments, essential oils may be mixed with acarrier oil 1:10, and 10 drops are placed under the tongue. Anothermethod of delivery is the patient inhales through the mouth, exhalesslowly through the nose=EO “vaping”. Essential oils Target neurological,nasal, oral, throat, respiratory, and systemic symptoms. These deliverymethods may provide rapid relief in minutes of patient's most urgentsymptoms.

Lavender EO may be used for neurological symptoms of pain, headaches,swelling, inflammation, anxiety, racing thoughts, inability toconcentrate, stress response—Lavender essential oil in a carrier oil1:10, sublingual maximum adult dose 160 mg/day—Paired with breathingtechnique to engage parasympathetic.

Spearmint EO may be used for systemic burning, heat symptoms, muscle andjoint pain, inflammation, rashes, headaches, nausea, vomiting,respiratory issues—Spearmint essential oil in a carrier oil 1:10,sublingual maximum adult dose 115 mg/day—Paired with breathing techniqueto engage parasympathetic.

Peppermint EO may be used for lack of focus, drowsiness, memoryproblems, inability to concentrate, heat symptoms, rashes—Peppermintessential oil in a carrier oil 1:10, sublingual maximum adult dose 152mg/day—Paired with breathing technique to engage parasympathetic.

Lemongrass EO may be used for symptoms of anxiety, insomnia, seizures,digestion issues, mold toxicity, menstruation problems, bladder issues,headaches, cramps, rheumatism—Lemongrass essential oil in a carrier oil1:10, sublingual maximum adult dose 46 mg/day—Paired with breathingtechnique to engage parasympathetic.

Eucalyptus globulus EO may be used for symptoms of inflammation, moldtoxicity, respiratory issues, lack of focus, pain—Eucalyptus globulusessential oil in a carrier oil 1:10, sublingual maximum adult dose 600mg/day—Paired with breathing technique to engage parasympathetic.

Each of these EOs may be contraindicated for certain patients havingcertain conditions. They may also cause side effects. A practitionerskilled in the art may be able to avoid or minimize side effects and/oradministration of contraindicated EOs to patients, based on anexamination of the patient and their history, and based on the presentdisclosure and information known in the art.

Within 24 hours after antibiotic treatment of the spirochetal infectionssyphilis, Lyme disease, leptospirosis, and relapsing fever (RF),patients experience shaking chills, a rise in temperature, andintensification of skin rashes known as the Jarisch-Herxheimerreaction(JHR). Experimental evidence by the present inventor indicates it iscaused by nonendotoxinpyrogen and spirochetal lipoproteins. Mediation ofthe HerxheimerReaction in RF by the pro-inflammatory cytokines tumornecrosis factor (TNF), interleukin-6 (IL)-6, and interleukin-8 (IL-8)has been proposed.

Essential oils may reduce inflammatory cytokines in lab and animalstudies. Herbal clinical results in Chinese hospitals are showingcytokine reduction and blood detoxification, and compounds which mayblock COVID-19 replication and cell penetration based on molecularmodelling and lab studies on sars and COVID-19. Spearmint 115 mg/dayadult dose (significantly reduced TNF-alpha, IL-1beta, and theexpression of MMP-9, enhances Nrf2 protein expression). Eucalyptusglobulus 600 mg/day adult dose (reduced inflammatory IL-1β, IL-4, IL-5,IL-6, IL-8, and TNF-α)

Turmeric 500 mg/day adult dose (Reduced MMP-2, MMP-9, cluster ofdifferentiation 45 (CD45), TNF-α, interferon-γ (IFN-γ), IL-1β, IL-6,COX-2. Turmeric increased superoxide dismutase (SOD), glutathione, andglutathione reductase enzyme levels in blood andglutathione-S-transferase in the liver.

A liposome is a spherical vesicle having at least one lipid bilayer, isusually made with a phospholipid. Liposomes can be used as a vehicle foradministration of essential oils or drugs to a subject. Liposomalessential oils may be able to target recurring symptoms, systemicinfections, toxicity, inflammation in hard to reach reservoirs:cartilage, blood cells, collagen, nervous system, under biofilms.Liposomes form a barrier around their contents, which is resistant toenzymes in the mouth and stomach, alkaline solutions, digestive juices,bile salts, and intestinal flora that are generated in the human body,as well as free radicals. The contents of the liposomes are protectedfrom oxidation and degradation. Liposomal oils can interact with severalcell types including infected cells. This could also be a promisingtreatment for microbial infections.

Microparticle essential oils have antimicrobial properties. The smallsize of essential oil particles has a high surface tension. They fusewith and subsequently disrupt the membrane of isolated prokaryoticcells, viruses, and eukaryotic cells of fungi. They also do not affecteukaryotic cells of higher organisms.

Liposomes penetrate deeper into blood brain barrier, inside of cells,i.e. pathogen reservoirs.

As a natural and safe spice, the cinnamon oil exhibited a satisfactoryantibacterial performance on MRSA and its biofilms. The application ofliposomes further improves the stability of antimicrobial agents andextends the action time.

The present inventor has shown that encapsulating silver (as the ionAg+) and tea tree oil (singly and in combination) in a controlledrelease liposomal carrier system can improve their antimicrobialefficacy as well as reduce the effective concentration required. Thesefindings may impact on the problems of agent toxicity caused by the needfor high effective doses or microbial resistance where long termapplication is required.

The combination of EO with fluoroquinolones, doxycycline, lincomycin,and maquindoxflorfenicol to treat ESBL-producing E. coli infections maylower, to a great extent, the effective dose of these antibiotics andthus minimize the side effects of antibiotics.

Thyme and peppermint EOs, and their active components and ciprofloxacininhibit/eradicate biofilms of K. pneumoniae. There is a pronouncedsynergistic relationship between piperacillin/cinnamon bark oil,piperacillin/lavender oil, piperacillin/peppermint oil as well asmeropenem/peppermint oil against two MDR bacteria strains. Amoxicillinantibacterial activity can be enhanced using active constituents presentin oregano against the Methicillin-resistant Staphylococcus aureusinfections.

A synergistic interaction was observed against all fifteen differentstrains of Gram positive and Gram-negative bacteria with theassociations between the essential oils Pelargonium graveolens (GeraniumEgypt)/Gentamicin. Myrtle oil showed significant antifungal activitywhen combined with amphotericin B against Candida albicans, differentspecies of Aspergillus (A. niger, A. parasiticus, Aspergillus flavus).Lavender oil has the potential to reverse bacterial resistance topiperacillin in E. coli. Antibiotics+Essential Oils Combined. Basilessential oil combined with imipenem may increase antibacterial activityagainst S. aureus, and basil oil combined with ciprofloxacin workedsynergistically against P. aeruginosa. Peppermint oil combined withgentamicin showed synergistic activity against Klebsiella pneumoniae.Caraway essential oil demonstrated synergy with gentamicin against K.pneumoniae. An additive effect was observed for gentamicin combined withthyme, fennel, basil, and clary sage against K. pneumoniae.

Tea tree oil, coriander and apple mint essential oils when used incombination with gentamicin and fluconazole showed a synergic effect onsome bacteria and fungi. Caraway essential oil in combination withvancomycin demonstrated a potent synergistic effect against S. aureus.

An unexpectedly advantageous synergistic effect was found of fourcomponents of essential oils (thymol, eugenol, berberine andcinnamaldehyde) combined with streptomycin on planktonic andbiofilm-associated food-borne pathogens Listeria monocytogenes andSalmonella typhimurium. Rosemary essential oil/ciprofloxacin displayed afavourable synergistic effect against K. pneumoniae. This patient wasreferred to a medical provider who administered intravenous silver,artesenuate, NAD+.

Improved with neurofeedback, Feeling 90% better. Symptoms are all goneexcept for occasional waking up in the middle of the night. Patient hadmultiple symptoms possibly due to a chronic herpes infection he may havegotten from a relationship. He tried antibiotics and supplements whichdid not help his symptoms. The inventor contracted with another companyto provide an experimental scan to detect frequencies of underlyinginfections. HHV6 was one of the infections detected. The inventorprovided customized microparticle remedies to the patient. He feltbetter when taking the remedies. He had lingering symptoms of fatigueand mental uneasiness. He was referred to another practitioner for IVtreatments.

Referred to intravenous therapies (silver, artesenuate, NAD) ⋅Improvedwith neurofeedback. ⋅Feeling 90% better. —Symptoms are all gone exceptfor occasional waking up in the middle of the night.

There are many challenges to diagnosing and helping people to healchronic Lyme disease and multiple infections. It is a matter of findingthe real underlying reasons and effective remedies and treatments—themost effective formulation for each patient may not be foundimmediately. It may take several tries. In order to target underlyinginfections, customized essential oil remedies give you a greater chanceof success

In view of the present disclosure, the inventor believes that oneskilled in the art would be able to determine suitable compositions,based on the present-indicated factors.

According to non-limiting example embodiments, the therapy orcomposition may be a combination formulation with more than one activeingredient, such as essential oils, herbs and/or supplements, or atherapy or composition to try to achieve more than one result. In anysuch combination therapy, the respective manufacturing processes andchemical environments would have to be compatible with one another.Example compositions may be quite useful in being able to provide acombination therapy composition for the treatment of at least twodifferent infections or diseases in a single dosage form.

Also included herein are kits and/or systems that include one or more ofthe present microparticle compositions provided herein or one or morecomponents of the compositions. The kits or systems may further includeone or more of the following additional components, items, or otheringredients typically present in composition kits: instructions for use,administration implements or devices (such as vials, disinfectant wipes,etc.), disposable implements, additional treatment literature,additional implements or compositions for the treatment of variousconditions treated by administration of the present substances ofinterest, such as e.g., anti-inflammatories, etc. In exampleembodiments, kits may include optionally one or more additionalcomponents to aid in the delivery of the microparticle composition to asubject in need thereof and/or instructions for administration.

The following are non-limiting example embodiment ofcompositions/formulations that may be used in accordance with thepresent invention and methods of their use.

EXAMPLES Example 1

Based on case studies with patients, provided is a non-limiting examplecombination composition of microparticle essential oils that wereeffective in patients diagnosed with Bartonella:

Carrot seed EO 4%, celery seed EO 8%, cinnamon bark 1%, clove bud EO 1%,German chamomile EO 8%, copaiba EO 8%, geranium EO 4%, helichrysum EO4%, lemongrass EO 13%, mountain savory EO 4%, oregano EO 5% spearmint EO4%, and organic sunflower lecithin 36%, and reverse osmosis water wasused. Other types of purified water may be used.

In this example, the essential oils were formed into microparticlesusing the sonication method.

Example 2

Based on other case studies, provided is a non-limiting examplecombination composition of microparticle essential oils, whichcomposition was effective in patients diagnosed with Borrelia andBabesia infections:

Roman chamomile EO 8%, cardamom seed EO 2%, cinnamon EO 1%, helichrysumEO 8%, lavender EO 8%, lemon balm 4%, thyme EO 12%, organic sunflowerlecithin 37%, and reverse osmosis water.

In this example, the essential oils were formed into microparticlesusing the sonication method.

Example 3

Based on other patient case studies, provided is a non-limiting exampleof a combination composition of microparticle essential oils that waseffective in patients diagnosed with Borrelia infection:

Bergamot EO 2.5%, carrot seed EO 2.5%, Roman chamomile EO 5%, hyssop EO2.5%, lemongrass EO 5%, marjoram EO 10%, nutmeg EO 5%, petitgrain EO2.5%, thyme EO 10%, organic sunflower lecithin 65%, reverse osmosiswater.

In this example, the essential oils were formed into microparticlesusing the sonication method.

Example 4

Based on research studies, provided are non-limiting examples ofcombinations of essential oils that may be effective in patientsdiagnosed with, or suspected of having, a Covid-19 infection:

Bay Laurel EO 20%, Eucalyptus globulus EO 15%, organic sunflowerlecithin 65%, reverse osmosis water.

Herba houttuyniae 8%, Ganoderma 8%, Folium isatidis 4%, Radixscutellariae 4%, Galla chinensis 4%, Radix astragali 4%, Radix etRhizoma glycyrrhizae 3%

Other herbs with anti-Covid-19 properties which may be included in theabove or other formulations used to treat patients with a Covid-19infection include Folium mori, Flos chrysanthemi, Flos loniceraejaponica, Fructus forsythia, and/or Herba moslae, Rhizoma zingiberis,and Folium eriobotryae.

These herbs would be processed using one of the microencapsulationmethods described above into microparticles which may be encapsulated inphosphatidylcholine from organic sunflower lecithin 65% and reverseosmosis water and may also be used for the treatment of Covid-19.

Although the present disclosure has been described in exampleembodiments, additional modifications and variations would be apparentto those skilled in the art. It is therefore to be understood that thepresent disclosure herein may be practiced other than as specificallydescribed. Thus, the present embodiments should be considered in allrespects as illustrative and not restrictive. Accordingly, it isintended that such changes and modifications fall within the scope ofthe present disclosure.

I claim:
 1. A microparticle composition comprising: one or moreingredients selected from essential oils, herbs, and supplements, thathave been modified or synthesized to be in microparticle form; whereinsaid one or more essential oils, herbs, and supplements in microparticleform are formulated to be pharmaceutically acceptable for administrationin an effective amount to a subject, for treatment of an infection ordisease in the subject, wherein the infection or disease is a Lyme tickborne illness related infection or disease, or a coronavirus.
 2. Themicroparticle composition of claim 1, wherein the Lyme tick borneillness related infection or disease comprises one or more of infectionor disease selected from the group consisting of Borrelia, Bartonella,Babesia, Ehrlichia, Anaplasmosis, Rickettsia, Mycoplasma, viruses,parasites, fungi, bacteria, and other tick infection.
 3. Themicroparticle composition of claim 2, wherein the composition comprisesmicroparticles of one or more of the following ingredients, Carrot seedessential oil (EO), celery seed EO, cinnamon bark, clove bud EO, Germanchamomile EO, copaiba EO, geranium EO, helichrysum EO, lemongrass EO,mountain savory EO, oregano EO, spearmint EO, organic sunflowerlecithin, Roman chamomile EO, cardamom seed EO, cinnamon EO, lavenderEO, lemon balm, thyme EO, organic sunflower lecithin, Bergamot EO,hyssop EO, marjoram EO, nutmeg EO, petitgrain EO, and thyme EO.
 4. Themicroparticle composition of claim 3, further comprising purified water.5. The microparticle composition of claim 1, wherein the coronavirus isCovid-19.
 6. The microparticle composition of claim 5, wherein thecomposition comprises microparticles of one or more of the followingingredients Bay Laurel EO, Eucalyptus globulus EO, organic sunflowerlecithin, Herba houttuyniae, Ganoderma, Folium isatidis, Radixscutellariae, Galla chinensis, Radix astragali, Radix et Rhizomaglycyrrhizae, Folium mori, Flos chrysanthemi, Flos lonicerae japonica,Fructus forsythia, Herba moslae, Rhizoma zingiberis, and Foliumeriobotryae.
 7. The microparticle composition of claim 6, furthercomprising purified water.
 8. The microparticle composition of claim 1,wherein the one or more essential oils, herbs, and supplements, aremodified or synthesized into one or more microparticle forms selectedfrom the group consisting of liposomes, nanoparticles, nanostructuredlipid carriers, and nano-emulsion compositions.
 9. A method of makingthe microparticle composition of claim 1 comprising: combining the oneor more of the essential oils, herbs, and supplements; and modifying theessential oils, herbs, and supplements into microparticle form.
 10. Themethod of claim 9, wherein the one or more essential oils, herbs, andsupplements are modified into one or more microparticle forms selectedfrom the group consisting of liposomes, nanoparticles, nanostructuredlipid carriers, and nano-emulsion compositions.
 11. The method of claim9, wherein the one or more essential oils, herbs, and supplements aremodified into microparticle form using sonication.
 12. A method oftreating a subject having a Lyme tick borne illness related infection ordisease, or a coronavirus infection, comprising administering to thesubject the microparticle composition of claim 1 comprising one or moreingredients selected from essential oils, herbs, and supplements, thathave been modified or synthesized to be in microparticle form, in aneffective amount to treat the Lyme tick borne illness related infectionor disease, or a coronavirus infection.
 13. The method of claim 12,wherein the subject is a mammal.
 14. The method of claim 12, wherein themicroparticle composition is administered to the subject by a methodselected from the group consisting of orally, nasally, rectally,vaginally, topically, intravenously and injection.
 15. The method ofclaim 12, wherein the Lyme tick borne illness related infection ordisease comprises one or more of infection or disease selected from thegroup consisting of Borrelia, Bartonella, Babesia, Ehrlichia,Anaplasmosis, Rickettsia, Mycoplasma, viruses, parasites, fungi,bacteria, and other tick infection.
 16. The method of claim 15, whereinthe composition comprises microparticles of one or more of the followingingredients, Carrot seed EO, celery seed EO, cinnamon bark, clove budEO, German chamomile EO, copaiba EO, geranium EO, helichrysum EO,lemongrass EO, mountain savory EO, oregano EO, spearmint EO, organicsunflower lecithin, Roman chamomile EO, cardamom seed EO, cinnamon EO,lavender EO, lemon balm, thyme EO, organic sunflower lecithin, BergamotEO, hyssop EO, marjoram EO, nutmeg EO, petitgrain EO, and thyme EO. 17.The method of claim 12, wherein the coronavirus comprises COVID-19. 18.The method of claim 17, wherein the wherein the composition comprisesmicroparticles of one or more of the following ingredients Bay LaurelEO, Eucalyptus globulus EO, organic sunflower lecithin, reverse osmosiswater, Herba houttuyniae, Ganoderma, Folium isatidis, Radixscutellariae, Galla chinensis, Radix astragali, Radix et Rhizomaglycyrrhizae, Folium mori, Flos chrysanthemi, Flos lonicerae japonica,Fructus forsythia, Herba moslae, Rhizoma zingiberis, and Foliumeriobotryae.
 19. The method of claim 12, wherein the one or moreessential oils, herbs, and supplements; are modified into one or moremicroparticle forms selected from the group consisting of liposomes,nanoparticles, nanostructured lipid carriers, and nano-emulsioncompositions.
 20. A kit comprising one or more microparticlecompositions according to claim 1 or a component or ingredient thereofand optionally one or more additional components to aid in the deliveryof the microparticle composition to a subject in need thereof and/orinstructions for administration.